Drug Interactions with Common ED Prescription Medications

Testosterone may help open up (vasodilate) your blood vessels, which helps blood flow to your penis. Injuries (trauma) to your penis and surrounding areas can also cause ED. Injuries to your pelvis bones (hip bones, sacrum and tailbone), bladder, prostate and spinal cord. Pelvic surgery, including prostate, colon or bladder cancer surgery. Erectile lovegra 100 mg dysfunction is a common side effect of many prescription drugs.

Premature Ejaculation (PE)

It’s important to talk to a healthcare provider if you have problems getting and maintaining an erection. Healthcare providers separate ED into several categories: Vascular ED includes causes that affect the blood vessels that send blood to the tissues in your penis that allow you to get and maintain an erection, or the valves in the penis that normally hold blood inside. Vascular ED is the most common type of ED. Neurogenic ED occurs as a result of nerve problems, which prevent signals from traveling from your brain to your penis to create an erection. This can happen because of trauma, pelvic surgery, radiation therapy or neurologic conditions like stroke, spinal stenosis and multiple sclerosis (MS).

Other medicines

Hormonal ED refers to ED that happens as a result of testosterone deficiency, or in some cases as a result of thyroid issues. Psychogenic ED involves psychological conditions (conditions that affect your thoughts, feelings or behavior) that can cause ED. Erectile dysfunction is the most common sex-related condition that males report to healthcare providers, especially as they age and develop other health issues. Providers and medical researchers estimate that erectile dysfunction affects over 50% of males between the ages of 40 and 70. And those numbers may be higher — many don’t seek help for the condition due to embarrassment or shame. Common medications that list ED as a potential side effect include: Substances that have addiction potential may cause ED, including: These substances can affect and suppress your central nervous system. They can also cause severe damage to your blood vessels, which may lead to permanent erectile dysfunction.

• First-line treatment: Usually oral PDE5 inhibitors due to efficacy and ease of use.
• Second-line treatment: Includes intracavernosal injections or intraurethral suppositories.
• Third-line treatment: Includes vacuum devices and surgical penile implants.
• Step-care model: Progressing from least invasive to more invasive treatments.
• Treatment goals: To achieve erections sufficient for satisfactory sexual intercourse.
• Success rates: Vary by treatment; PDE5 inhibitors work for about 60-80% of men.
• Treatment adherence: Side effects, cost, and psychological factors affect continued use.
• Combination approaches: Using psychological therapy alongside medical treatment.
• Follow-up care: Important to assess effectiveness and adjust treatment as needed.
• Treatment discontinuation: Reasons include cost, side effects, or loss of a partner.

Fear of sexual intercourse or intimacy (genophobia). Conditions that affect your body’s ability to deliver blood to your penis are the most common cause of ED.

Rank	Drug Name	Estimated Sales (USD Millions)	Market Share (%)
1	Sildenafil	950	45
2	Tadalafil	700	33
3	Vardenafil	150	7
4	Avanafil	100	5

You may have a greater risk of getting ED if you: Have a body mass index (BMI) over 25. A healthcare provider can diagnose ED and determine its cause. They’ll review your medical history and perform a physical exam. They’ll also ask you questions about your personal and sexual history. These questions may make you feel embarrassed or awkward. But it’s important to be honest with the provider in order to quickly determine the cause.

Product	Dosage	Quantity + Bonus	Price
Viagra Original	100mg	76 + 4 Pills	306.59€ 291.99€	Buy
Cialis Soft Tabs	20mg	90 + 6 Pills	216.71€ 206.39€	Buy
Kamagra 100 mg	100 mg	32 Pills	121.24€ 115.47€	Buy
Levitra Original	20mg	92 + 4 Pills	406.22€ 386.88€	Buy
Tadalista Super Active	20mg	60 + 8 Pills	230.32€ 219.35€	Buy
Kamagra Oral Jelly	100mg	63 + 7 Sachets	224.18€ 213.50€	Buy
Kamagra Polo	100 mg	20 Pills	83.56€ 79.58€	Buy
Cialis Generic	5mg	180 + 10 Pills	159.65€ 152.05€	Buy
Cialis Generic	20mg	20 Pills	54.72€ 52.11€	Buy
Levitra Soft Tabs	20mg	10 Pills	52.27€ 49.78€	Buy
Kamagra Soft Tabs	100 mg	60 + 4 Pills	180.59€ 171.99€	Buy
Kamagra 100 mg	100 mg	360 + 6 Pills	839.95€ 799.95€	Buy
Kamagra Polo	100mg	84 + 4 Pills	244.49€ 232.85€	Buy

Are you currently taking any medications, including prescription drugs, over-the-counter drugs, herbal supplements, dietary supplements and nonmedical drugs? Has a healthcare provider ever diagnosed you with depression or anxiety? How often are you able to get erections? How long are you able to maintain an erection? Do you lose your erection because you ejaculate sooner than you would like? When did you first notice symptoms of erectile dysfunction? What exactly happened when you first had erectile dysfunction symptoms? Do or did you experience erections at night or during the morning? What sexual positions do you regularly engage in? The provider may also ask to talk with your sexual partner. Your partner may be able to offer additional insight on potential causes. The provider may order tests to confirm their diagnosis and determine the cause of your ED.

How To Find The ED Medication That’s Right For You

Erectile dysfunction (ED) is a type of penile disorder. It affects your ability to get and maintain an erection firm enough for sexual intercourse. Your feelings play a major role in getting and maintaining an erection. Feeling relaxed, confident and aroused is essential. But it’s normal to sometimes have erection issues.

Cost of erectile dysfunction pills

Erection problems can occur if you feel nervous, anxious, frustrated or tired. Drinking alcohol and/or using substances can also have an effect. It can also result from other conditions or as a side effect of certain medications or cancer treatments. If you’re having difficulty getting or maintaining an erection, it’s a good idea to schedule an appointment with a healthcare provider for further discussion. In many cases, ED can be the first symptom of another underlying problem, including heart disease. It depends on what your healthcare provider suspects is causing erectile dysfunction. Tests that measure if the nerves in your penis respond to vibrations (penile biothesiometry). Drugs that temporarily make your penis erect (vasoactive injection). Before testing, your provider will explain what’s involved with a test and answer any questions you have. If you don’t feel comfortable, you can decide not to do the test at any time. The first step in treating erectile dysfunction is identifying the underlying cause. A healthcare provider will help determine the best treatment for you. Vigorous cardiovascular exercise for at least 45 minutes three times per week may help reverse some cases of mild ED. Cardiovascular exercises vardenafil vilitra 60 mg may include brisk walking, jogging, swimming, bicycling and jumping rope. For men with mild ED, quitting smoking can lead to improvement after several months.

• Insulin: Hormone for managing blood sugar in type 1 and insulin-dependent type 2 diabetes.
• Metformin: First-line medication for type 2 diabetes, improves insulin sensitivity.
• Glipizide: Sulfonylurea that stimulates insulin release in type 2 diabetes.
• Glyburide: Another sulfonylurea used to lower blood sugar levels.
• Pioglitazone: A thiazolidinedione that increases insulin sensitivity.
• Sitagliptin: DPP-4 inhibitor that enhances incretin levels, increasing insulin release.
• Liraglutide: GLP-1 receptor agonist that stimulates insulin secretion and reduces appetite.
• Canagliflozin: SGLT2 inhibitor that promotes glucose excretion via urine.
• Acarbose: Alpha-glucosidase inhibitor delaying carbohydrate absorption.
• Exenatide: Injectable GLP-1 receptor agonist for type 2 diabetes control.
• Insulin glargine: Long-acting insulin for basal glucose control.

Oral medications that help increase blood flow to your penis, including sildenafil (Viagra®), vardenafil (Levitra®), tadalafil (Cialis®) or avanafil (Stendra®). Oral medications start to work within an hour. Penile low-intensity focused shockwave therapy (LiSWT).

Drug Name	Mechanism	Onset of Action	Duration
Sildenafil	PDE5 inhibitor	30-60 minutes	4-6 hours
Tadalafil	PDE5 inhibitor, PDE11 inhibitor	30-60 minutes	Up to 36 hours
Vardenafil	PDE5 inhibitor	30-60 minutes	4-5 hours
Avanafil	PDE5 inhibitor	15-30 minutes	6 hours

This noninvasive treatment improves blood flow by using sound waves. It can take two months to see improvement. Medications you inject directly into your penis to create an erection, including alprostadil (Caverject®), papaverine (Papacon®), phentolamine (Regitine®) or a combination of multiple medications. Injectable medications start to work within 10 minutes. Penis pumps start to work almost immediately. Testosterone replacement therapy, which is available as a gel, injection, patches and pellets. Testosterone replacement therapy starts to work within four weeks. A penile implant is a procedure in which a surgeon places a device into your penis to make it hard. The device doesn’t affect sensation, peeing or orgasm. ED will not likely go away on its own without changes to your lifestyle or some kind of treatment. The outlook for ED is good and it’s a very treatable condition. Though there aren’t cures for some causes of ED, many treatment options can help you get and maintain an erection hard enough for sexual intercourse. Certain lifestyle changes can help lower your risk of developing erectile dysfunction, including: Being more physically active, especially doing cardiovascular exercises like running, jogging or bicycling. Eating healthy foods with low saturated fats, such as fruits, vegetables and whole grains.

What special dietary instructions should I follow?

Only sometimes being able to get an erection before sexual intercourse. Being able to get an erection before sexual intercourse but not being able to maintain it during sexual intercourse. Requiring a lot of stimulation to maintain an erection. There are many possible causes of ED, including conditions that affect your: Your circulatory system includes the blood vessels that carry blood throughout your body. Your penis needs adequate blood flow to become erect and maintain an erection.

Phosphodiesterase Type 5 Inhibitors

Your penis also relies on a series of valves to close when it fills with blood — in some cases, these valves stop working as they should. Your nervous system includes your brain, spinal cord and nerves. They work together to send electrical impulses that help your body move and feel, including your penis. Your endocrine system includes the glands that create and release hormones. Hormones help tell your body to perform certain functions. Talk to a primary care physician or a urologist if you suspect you have erectile dysfunction.

Should I Get Surgery for Erectile Dysfunction?

Read 5 natural ways to overcome erectile dysfunction. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Erectile dysfunction (ED) is the inability to get or maintain an erection long enough to have sexual intercourse.

Altitude sickness

There are many different causes, which may include conditions that affect your blood vessels, neurological conditions, mental health conditions and injuries. A healthcare provider can diagnose and treat erectile dysfunction. Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. They can help diagnose ED, identify its cause and recommend the best treatment option for you. A urologist is a healthcare provider who specializes in diagnosing and treating conditions that affect your reproductive system and urinary system. Go to your nearest emergency room if you’re taking medication for erectile dysfunction and have a painful erection that lasts longer than two to four hours. This may be a sign of priapism, which can cause permanent damage to your penis without treatment. Is it normal to have erectile dysfunction? How do you know I have erectile dysfunction? What ED treatment option do you recommend? Can erectile dysfunction cause other conditions that affect my sexual health? Can you recommend a support group for people who have erectile dysfunction? Am I a candidate for a penile implant procedure? Erectile dysfunction can cause you to feel many different emotions. You may feel embarrassed, frustrated, guilty, ashamed, angry or “less than.” This can lead to more serious long-term emotions, like anxiety and depression. But you don’t have to live with these feelings. ED is common, and it doesn’t reflect your worth as a person. Erectile dysfunction is a sensitive topic for many people.

• Age-related ED: Natural decline in erectile function is common with aging.
• Diabetes management: Tight glycemic control can help prevent or improve ED.
• Hypertension management: Controlling high blood pressure improves vascular health.
• Statin medications: Used for cholesterol, may improve endothelial function and ED.
• Metformin: A diabetes drug that may have a positive effect on erectile function.
• The impact of recreational drugs: Cocaine, marijuana, and opioids can cause ED.
• Anabolic steroid abuse: Can shut down natural testosterone production, causing ED.
• Performance anxiety: A common psychological cause of situational ED.
• Sensate focus exercises: A therapy technique to reduce anxiety and increase intimacy.
• Dilators for ED: Used in physical therapy to address pelvic floor muscle tension.