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While headache, gastrointestinal (GIT) upset, and muscle and back

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pains were significantly reported among patients receiving tadalafil 5

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This survey is being conducted by the WebMD marketing sciences department. We aimed to compare the efficacy, safety, and compliance of tadalafil 5 mg daily dose in the tablet form versus oral dispersible film (ODF) in men with mild-to-moderate erectile dysfunction (ED). One hundred thirty-five randomized patients were equally divided into three groups according to age where each group included forty-five patients. Within each group, 15 patients received oral tadalafil 5 mg, 15 patients received ODF tadalafil 5 mg and 15 patients received a placebo once daily for 1 month. All participants were assessed by the validated Arabic version of the international index of erectile function (ArIIEF-5) at baseline and after 1 month.

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Also, the efficacy of different forms of tadalafil 5 mg was assessed by responding affirmatively to a questionnaire. Patients aged > 25 to < 40 years and 40–55 years and > 55 years showed a statistically significant improvement of ArIIEF-5 scores after tadalafil 5 mg tablet and ODF tadalafil 5 mg compared to placebo ODF (23 ± 1.4; 22.7 ± 0.9; 20 ± 0.9; 20.4 ± 1.3; 20.2 ± 1.2; 16.6 ± 1.2; 18.5 ± 1.7; 19.6 ± 1.4; 16.3 ± 1.4; p < 0.001, respectively). Three patients (> 25 to < 40 years) who received tadalafil 5 mg tablet showed muscle and back pain. Gastrointestinal (GIT) upset (eight patients) followed by headache (seven patients) were the main side effects reported in patients (40–55 years) who received tadalafil 5 mg tablet. While GIT upset was the main side effect reported in patients (> 55 years) who received tadalafil 5 mg tablet. mg tablet compared to other formulations in group B

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(p < 0.001, < 0.001, and 0.012, respectively) (Table 2).

Benefit	Description	Evidence Level	User Feedback
Rapid absorption	Fast onset of effect, within 15 minutes	High	Positive
Convenience	Easy to use, no water required	High	Positive
Discreet usage	Portable, discreet in social settings	High	Positive
Precise dosing	Standardized dosage per strip	Moderate	Mixed

Finally, GIT upset was significantly reported among patients receiving tadalafil 5 mg

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Data analysis was conducted using SPSS version 22nd; Qualitative data were presented by number and percentage, and quantitative data were presented by mean, standard deviation, minimum, and maximum. The Pearson Chi2 test was used to compare categorical variables between groups. Quantitative variables were presented in mean, standard deviation, minimum, and maximum. The Kruskal–Wallis test was used to compare quantitative variables between study groups. Socio-demographic characteristics are presented in Table 1. tablet compared to other formulations in group C (p < 0.001) (Table 2).

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Groups A, B, and C showed a statistically significant improvement in the ArIIEF-5 scores after treatment with tadalafil 5 mg tablet and ODF tadalafil 5 mg compared to ODF placebo (p < 0.001) (Table 2, Fig. The efficacy of ODF tadalafil 5 mg and tadalafil 5 mg tablet was markedly higher compared to placebo (p < 0.001). Improvement in both formulations was reported in all patients compared to placebo across all groups. Compliance was significantly higher among patients on ODF tadalafil 5 mg compared to tadalafil 5 mg tablet in groups B and C, respectively (p < 0.001) (Table 2). Regarding adverse effects, muscle and back pains were significantly higher among patients receiving tadalafil 5 mg tablet compared to other formulations in group A (p = 0.040) (Table 2). The core findings of the current study were that

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Tadalafil is more selective for PDE5 than most other families of PDEIs [8]. Tadalafil had been developed as yellow film-coated tablets (FCTs) intended for oral administration [9]. They are available in several strengths, including 2.5 mg, 5 mg, 10 mg, or 20 mg. However, it is worth noting that this tablet formulation may provide challenges for patients with ED [9].The oral dispersible film (ODF) is a novel type of medication delivery that consists of a small strip of thin polymeric film like a postage stamp in size [10]. The film rapidly disintegrates or dissolves when it is placed on the tongue, allowing for immediate drug release [10].

Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films

An ODF can rapidly dissolve and disintegrate within the oral cavity in less than 1 min [11]. The utilization of an ODF has demonstrated enhanced clinical efficacy of medications in comparison to conventional formulations such as tablets or capsules [12]. Enhancements to the taste and the performance of ODFs could be achieved by modifications to various constituents, such as film-forming polymers, active medicinal compounds, plasticizers, flavors, and sweeteners [10, 13]. ODF formulation could be taken without the need for water or chewing, which offered physicians and patients a novel and attractive option for the treatment of ED [14]. Furthermore, ODF formulation could provide a cost-effective alternative to conventional tablet formulation owing to recent developments in ODF manufacturing technology [14]. participants across all groups showed a statistically significant improvement

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Thus, we conducted a single-blinded, randomized, placebo-controlled clinical trial to compare the efficacy, safety, and compliance to tadalafil 5 mg daily dose in the tablet form versus ODF in men with mild-to-moderate ED as they were given once daily for 1 month. The once a day cialis study protocol was approved by the local ethical committee of Kasr Alainy Faculty of Medicine. Approval was granted on December 2022 (MS-24-2023) that conforms to Helsinki Declaration 2013 [15]. All participants were recruited from October 2022 to August 2023. Also, they signed a written informed consent after discussing all study procedures, potential risks, and anticipated benefits.

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Power of the study and sample size calculator was used for a non-inferiority randomized controlled study, with 0.05 alpha error and power of the study 0.80, 0.1 non-inferiority margin, and 2 enrollment ratios. Accordingly, 135 patients diagnosed with ED were needed to be enrolled and were randomized by simple numbering technique. Any married male patient ≥ 25 years old with regular heterosexual intercourse, 2–3 times/week in the previous 6 months prior to enrollment in the study presenting with mild-to-moderate ED was included. Patients with diabetes, hypertension, metabolic syndrome, malabsorption syndrome, ischemic heart disease, atherosclerosis, vasculitis, major psychological problems, or Peyronie’s disease were excluded from the current study. Those with post-priapism ED, a history of recent penile and/or urethral surgery or trauma, as well as uncorrected hypogonadism and contraindication to PDE5Is were excluded. in the ArIIEF-5 scores after tadalafil 5 mg tablet and ODF tadalafil 5 mg compared to ODF placebo.

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Furthermore, post hoc analysis showed that improvement

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ODF tadalafil 5 mg is an effective, tolerable, and safe formulation that can be used in patients with mild-to-moderate ED. Erectile dysfunction (ED) is a common condition that affects 20–40% of men between the ages of 60 and 69 years and more than 50% of men older than 70 years worldwide [1]. It affects around 20–30% of Egyptian married males [2]. Remarkably, the prevalence is projected to be 80% among patients with type 2 diabetes or metabolic syndrome [2]. Aging, depression, obesity, smoking, obstructive lung diseases, hypertension, dyslipidemia, socioeconomic class, rural residency, quality of life, and COVID-19 infection are all factors contributing to increased incidence and prevalence of ED among the Egyptian population during the past decade [3,4,5].

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The phosphodiesterase type 5 inhibitors (PDE5Is) sildenafil, tadalafil, vardenafil, and avanafil are the first line management of patients diagnosed with ED followed by self-administered intracorporal injection therapy using vasodilator drugs [6]. Moreover, surgical treatment of ED with multicomponent inflatable penile implants was associated with high satisfaction rates [6]. Brock and colleagues (2002) presented their initial data supporting the efficacy and safety of tadalafil [7]. Tadalafil was approved for use in Europe in late (2002), and in November (2003), it was approved by the FDA for use in the United States [7]. Tadalafil’s molecular structure is different than similar structures of sildenafil and vardenafil [8]. after tadalafil 5 mg tablet and ODF tadalafil

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5 mg was mainly significant compared to placebo, and both formulations were comparable in efficacy.

Side Effect	Severity	Frequency	Notes
Headache	Mild	Frequently	Resolved within hours
Flushing	Mild	Common	Usually temporary
Nasal congestion	Mild	Occasional	Usually self-limited
Dyspepsia	Mild	Rare	Related to intake

Patients who received ODF tadalafil 5 mg were significantly

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Finally, patients who tried PDEIs and experienced side effects were also excluded from the study. All patients who fulfilled the inclusion criteria were subjected to the following: medical and surgical histories were obtained from the participants. Furthermore, general and local examinations were done. All subjects answered a copy of the validated Arabic version of IIEF-5 (ArIIEF-5) separately at baseline and after 1 month [16]. Morning serum testosterone and prolactin (before 11 AM), total PSA (only in groups including men above 40 Y), glycosylated hemoglobin, random blood sugar, lipid profile were analyzed, and complete urine analysis was performed.

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Patients were equally divided into 3 groups according to age where each group included 45 patients. Group A was > 25 to < 40 years, group B was 40 to 55 years, and group C was > 55 years. Within each group, 15 patients received oral tadalafil 5 mg tablet and 15 patients received ODF formulations of tadalafil 5 mg as well as 15 patients received an ODF placebo (hydroxy profile methyl cellulose polymer and starch) for 1 month. Moreover, the efficacy of different forms of tadalafil was assessed by responding affirmatively to the following questions: “Are you satisfied with the effect of treatment on your erections?” and “If yes, has treatment improved your ability to engage in sexual activity?’’ [17]. Finally, all patients were evaluated for the presence of adverse effects such as headache, dizziness, palpitation, gastrointestinal upset, and muscle or back pain on a scale from 1 to 10. more compliant to treatment compared to tadalafil 5 mg tablet. (2018) stated that safety and tolerability features of the ODF formulation were

Ingredient	Function	Amount per strip	Source
Tadalafil	Active ingredient (PDE5 inhibitor)	10 mg	Pharmaceutical company
Mannitol	Filler, sweetener	1.2 mg	Natural sugar alcohol
Hypromellose (HPMC)	Film-forming agent	0.8 mg	Synthetic polymer
Aspartame	Artificial sweetener	0.05 mg	Synthetic
Flavors	Flavor enhancement	Varies	Food additive

found to be comparable to those of the film-coated tablet formulation [18].

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